I have come across more than a thousand students in my vocation as a spiritual teacher. Few of them are happy people, most are unhappy. Ask them the source of their unhappiness and many, if not all, will tell you the root cause is issues with relationships.
If you ask them, what does this lead to? Most will tell you that the health is affected. If you ask them what has caused the trouble in relationships, they will tell you that besides the gap in their individual dispositions, one partner getting over-involved in their professional life, often foments trouble for the full family. The idea to see here is how relationships, health and professional life are all inter-connected.